St. George is a town in Knox County, Maine, United States. It includes the villages of Port Clyde and Tenants Harbor, with the latter being town's commercial center. A favorite with artists, writers and naturalists, St. George is home to the Brothers and Hay Ledge nature preserve, comprising four islands off Port Clyde. The town's population stands …St. George is a town in Knox County, Maine, United States. It includes the villages of Port Clyde and Tenants Harbor, with the latter being town's commercial center. A favorite with artists, writers and naturalists, St. George is home to the Brothers and Hay Ledge nature preserve, comprising four islands off Port Clyde. The town's population stands at 2,594 residents, according to the 2020 Census.