Nature

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V

The A-loop present at the C terminus of the kinase domain spans about 25 amino acids of the c-Kit receptor and is a region known for a number of activating mutations, including the D816V mutation.
ascopubs.org

KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape

Progressing lesions of 25 patients with GISTs refractory to ripretinib were sequenced for KIT resistance mutations. Resistant genotypes were validated and characterized using novel cell line models ...
Nature

A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors

The splicing of nuclear pre-mRNA is a fundamental process for the expression of most metazoan genes. More than half of reported exonic mutations in human disease and cancers are due to ...
ascopubs.org

Somatic Activation of KIT in Distinct Subtypes of Melanoma

DNA-Repair Gene Polymorphisms Predict Favorable Clinical Outcome Among Patients With Advanced Squamous Cell Carcinoma of the Head and Neck Treated With Cisplatin-Based Induction Chemotherapy We ...
Business Insider

Bio-Techne Announces Release of GMP Cloudz™ Human T Cell Activation Kit

MINNEAPOLIS, May 11, 2020 /PRNewswire/ -- Bio-Techne Corporation (NASDAQ:TECH) today announced the release of the GMP Cloudz™ Human T Cell Activation Kit. This is the first GMP-grade kit within the ...
GEN

Human T Cell Activation and Expansion Kit

Akadeum Life Sciences announced the release of their human T cell activation & expansion kit with buoyancy activated cell sorting (BACS) microbubbles. The kit was designed to isolate, activate, and ...