A group of researchers at the University of Tokyo have spent years testing the limits of chemical bonds. And now, after years of work, they've finally explored an idea originally proposed in 1931: a ...

Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...