The Carolina Panthers lost to the Buffalo Bills, 40-9, at home on Sunday. Here are some immediate takeaways from the Week 8 matchup at Bank of America Stadium.

There’s always two ways to look at a win or loss for a team. Can the Carolina Panthers take anything positive away from their 31-point setback to the Bills?

The Bills, behind 38 rushing yards from running back James Cook, chugged downfield on the first touch—reaching the Panthers' 23-yard line. But linebacker Trevin Wallace sacked quarterback Josh Allen on a third-and-10 to keep Buffalo to a 45-yard field goal. Bills lead 3-0 with 7:14 left in the first quarter.

With starting quarterback Bryce Young sidelined by an ankle injury, Carolina lost its first game this season at Bank of America Stadium. Next up: Green Bay Packers at Lambeau Field.

The loss of Ed Oliver was a hit to the Bills defensive line, but they could be getting some help back in the near future. New York Jets running back Isaiah Davis (32) is tackled by Buffalo Bills defensive tackle T.J. Sanders (98), Sunday, September 14, 2025, in East Rutherford. / Kevin R. Wexler-NorthJersey.com / USA TODAY NETWORK via Imagn Images

The Panthers, thanks to a disappointing showing against the Bills, squandered their chance to shoot up across the power rankings.

Charlotte Observer reporters Alex Zietlow and Mike Kaye break down the latest in the world of the Carolina Panthers.

You would be hard-pressed to find anything positive about Dave Canales's team following the Carolina Panthers’ horrendous showing vs. the Buffalo Bills.

The Buffalo Bills fell to 4-2 with a debilitating loss at the hands of the Atlanta Falcons on Monday night, falling 24-14 following a dismal effort. It was the second straight defeat suffered by Buffalo, which now places them in second place in the AFC ...

Behind 216 rushing yards and two touchdowns from James Cook the Buffalo Bills get back in the win column in a lopsided 40-9 win over the Carolina Panthers on Sunday in Charlotte, North Carolina.