Neurodegenerative disorders are pressing global health challenges that stem from progressive neuronal dysfunction and loss. While the central roles of ...

Cytochrome P450 enzymes constitute a highly diverse superfamily that is pivotal in the metabolism of endogenous and exogenous compounds. In the context of cancer research, members such as CYP1B1 and ...

Brain cytochrome P450 (CYP) enzymes represent a specialised set of metabolic proteins that, while less abundant than their hepatic counterparts, play an increasingly acknowledged role in the local ...

Most antidepressants are metabolized through the cytochrome P (CYP) 450 pathway; therefore, most drug metabolism genes on pharmacogenetic testing panels are related to CYP450 oxidase enzyme subunits.

Cytochromes P450 are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. Suppressed drug metabolism was identified in patients with various inflammatory conditions.

A number of studies have highlighted that ethnicity is an important factor influencing the genetic variability of some CYP450 enzymes and that human adaptation could have a role in shaping the genetic ...

Paracetamol is one of the most widely used, studied, and arguably the most notorious hepatotoxic drugs, which is safe at therapeutic doses but causes liver failure when overdosed. When administered at ...