San Francisco 49ers running back Christian McCaffrey left the game against the Buffalo Bills in the second quarter after suffering a non-contact injury, and was later ruled out. McCaffrey had just ...

Christian McCaffrey’s night took an unfortunate turn due to injury during the San Francisco 49ers’ matchup against the Buffalo Bills. The running back’s abrupt departure from the game due to a knee ...

From injury woes to NFL's Comeback Player, Christian McCaffrey roared back, dominating the field and redefining his elite status.

Getting your Trinity Audio player ready... By JOHN WAWROW ORCHARD PARK, N.Y. (AP) — San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as ...

San Francisco 49ers running back Christian McCaffrey put together a massive 2025 season, but that may spell doom for the 2026 campaign.