One of the longstanding challenges in the synthesis of pharmaceuticals, cosmetics and food additives is the continuous regeneration of molecules called cofactors that permit the synthesis through ...

Little is currently known about the molecular determinants of energy barriers along enzyme catalytic pathways. Kern and co-workers have studied this question in adenylate kinase (Adk) and now reveal ...

A peptide bridge is designed to construct a fusion enzyme with electrostatic cofactor channeling, reducing NADPH input by two orders of magnitude or decreasing reaction time threefold with the same ...

Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its ...

“Enzyme cascades” are important for biocatalytic transformations in biological cells. These processes involve complex networks and take place in spatially confined microenvironments. A team of ...

This is done by enzymes. Each enzyme is supported by a so-called cofactor, sometimes referred to as a "helper molecule." In a similar way, bacteria can "consume" ethylene glycol, using enzymes and ...

Although many organisms respond to light, very few enzymes inside those organisms use light directly as an energy source for catalysis. Researchers now report a new light-driven enzyme: Christened ...

Cells use flavin monooxygenases to break down foreign molecules by adding oxygen atoms to them. Biochemists have long assumed that the enzymes use a particular cofactor adduct to add the oxygen. A new ...

Enzymes perform very specific functions and require only little energy -- which is why the biocatalysts are also of interest to the chemical industry. Biologists have now provided a summary on what is ...

Enzymology is the study of enzymes and enzyme-catalyzed reactions. Enzymes are biological catalysts that accelerate the rate of biological reactions. They can also perform multiple reactions ...