In gene therapy, promoters act as vital “on/off” switches, dictating whether a therapeutic gene is active and to what extent. While delivery vehicles such as adeno-associated viruses (AAVs) can bring ...

Weekly nab-paclitaxel in combination with cisplatin as neoadjuvant chemotherapy in patients (pts) with locally advanced esophageal squamous cell carcinoma (SCC): Preliminary results of a phase study.

Inducible promoters provide remarkable utility when sustained transgene expression compromises plant development or agronomic ...

A recent study in genetic control elements revealed around 11,000 gene regulators active in every cell type, also known as housekeeping cis-regulatory elements (HK-CREs). These elements are vital in ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

Around 98.5% of human DNA is non-coding, meaning it doesn’t get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for ...

For those born with certain types of congenital deafness, the cochlear implant has been a positive and enabling technology.