The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...
The majority of base pairs in double-stranded DNA exist in the canonical Watson-Crick geometry. However, they can also adopt alternate Hoogsteen conformations in various complexes of DNA with proteins ...
Thermodynamic preferences to form non-native conformations are crucial for understanding how nucleic acids fold and function. However, they are difficult to measure experimentally because this ...
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