The innate immune response is the body’s first line of defence, utilising specialised protein complexes known as inflammasomes to detect pathogenic insults and cellular damage. These multi‐protein ...

The inflammasome, a multiprotein complex, plays a crucial role in the field of innate immunity. It is activated by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular ...

“These are the first data to link ASC speck assembly, NLRP1 inflammasome activation, and alpha-synuclein aggregation in neurons of Parkinson’s disease patients,” said Stephen C. Glover, ZyVersa’s ...

ZyVersa Therapeutics, in collaboration with the University of Miami Miller School of Medicine and with support from the Michael J. Fox Foundation, has published promising data on its inflammasome ASC ...

New research has explained how the body's internal clock influences the inflammatory process of the immune system. The findings describe how immune cells, called macrophages, work differently at ...

Tuesday, 17 December 2024: New research from RCSI University of Medicine and Health Sciences has explained how the body’s internal clock influences the inflammatory process of the immune system. The ...

NEWTON, Mass.--(BUSINESS WIRE)--Inflammasome Therapeutics (https://www.inflam.com/), a clinical-stage biotech company developing novel, first-in-class dual ...

Researchers at the University of Washington and Fred Hutch found that CARD8, an inflammasome sensor, detects HIV-1 in macrophages during cell-to-cell viral transmissions from infected T cells. HIV can ...

New research from RCSI University of Medicine and Health Sciences has explained how the body’s internal clock influences the inflammatory process of the immune system. The findings describe how immune ...

Itaconate, an endogenous mitochondrial metabolite produced by the enzyme aconitate decarboxylase 1 (ACOD1), has emerged as a central regulator of ...

Study supported by the Michael J. Fox Foundation through a grant awarded to ZyVersa and leading inflammasome experts at University of Miami Miller School of Medicine who conducted the study. Parkinson ...