3D reconstruction of a microscope image: red is the membrane and green is clumped prion protein. In order to gain new insights into the underlying processes, the researchers have developed new models ...

Membrane protein targeting and insertion is a fundamental process in cellular biology that ensures proteins are correctly delivered to, and integrated within, the lipid bilayer. Proteins destined for ...

This is a preview. Log in through your library . Abstract The ectodomain of proTGF-α, a membrane-anchored growth factor, is converted into soluble TGF-α by a regulated cellular proteolytic system that ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Collaboration between researchers at the University of Geneva, Institut de biologie structurale de Grenoble, and the University of Fribourg has shown how lipids and proteins in cell membranes react in ...

Proteins carrying a “tail anchor” must be inserted into the ER membrane before they can fulfill their cellular roles. In plants, this task is carried out by the Guided Entry of Tail-Anchored proteins ...

Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these ...

Membrane proteins are ubiquitous cellular components that are responsible for a wide array of cellular and molecular activities, including drug metabolism, lipid shuttling, and antibiotic resistance.

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ system, today announced the addition of a new membrane protein workflow to ...

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.