DNA hybridization thermodynamics is critical for accurate design of oligonucleotides for biotechnology and nanotechnology applications, but parameters currently in use are inaccurately extrapolated ...

Nucleic acids may be labeled at their 3’ end, 5’ end, or throughout the molecule, depending on the desired application. Myriad of enzymatic or chemical methods are utilized to generate nucleic acids ...

(Nanowerk Spotlight) Epigenetic mechanisms are chemical changes in DNA that do not alter the actual genetic code but can influence the expression of genes, and can be passed on when cells reproduce.

Whether one is elucidating biological mechanisms, correcting a faulty gene, or modulating gene expression, artificially introducing nucleic acids into cells requires an efficient and nontoxic delivery ...

In the case of nucleic acid tests, polymerase chain reaction (PCR) has been the gold standard for single-molecule diagnosis. Single-molecule detection of pathogens, such as severe acute respiratory ...