Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes ...

Opioid medications offer people relief from debilitating pain, but these drugs are associated with the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...

Talk about a dose of disappointment. A new analysis suggests that millions of Americans with chronic pain are being prescribed an opioid that does little to ease their suffering. To make matters worse ...

A new experimental painkiller has shown promise in dulling or eliminating pain without the addictive qualities exhibited by today's most popular opioids. The drug also sidesteps common opioid side ...

Prescribed safer opioid supply (SOS) and methadone both lead to better health outcomes among patients who use opioids, reducing overdoses, decreasing healthcare utilization, and reducing costs. The ...

Suboxone is now the standard of care in the U.S. for treating opioid addiction, but its downsides are often overlooked. RFK ...