Membrane-initiated estrogen receptor α (mERα) in specific cell types found crucial for bone strength
Researchers found that mice lacking membrane ERα signaling in osteoblast lineage cells had significantly lower cortical bone mass, highlighting the pathway’s critical role in maintaining the strength ...
PLAGL1-IGF2 signaling maintains metabolic balance and osteoblast differentiation in mandibular condyle, while PLAGL1 deficiency impairs bone formation. The mandibular condyle is a central growth site ...
A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...
Cell- and animal-based models of bone formation reveal novel mechanisms involved in the cartilage-to-bone phenotype ...
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