Researchers analyzed the role of NUDT5 and its interaction with other proteins in the folate pathway and in regulating purine synthesis.

Depurination of DNA and RNA sequences is an alteration of the sugar-phosphate backbone in which hydrolysis of a purine base (adenine or guanine) occurs. Synthetic oligonucleotides suffer from such ...

This image illustrates the chemical structures of the five main nucleobases found in DNA and RNA. The pyrimidines, thymine (DNA), uracil (RNA), and cytosine are shown on top while the purines, adenine ...

Acyclic nucleoside phosphonates (ANPs) represent a vital class of compounds with significant applications in antiviral and antiparasitic therapy. Characterised by a non-hydrolyzable phosphonate group, ...

Plants can fully catabolize purine nucleotides. A firmly established central intermediate is the purine base xanthine. In the current widely accepted model of plant purine nucleotide catabolism, ...

The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory ...