Chemical compound clears misfolded tau, protects neurons in a model of frontotemporal dementia

New research from Washington University School of Medicine in St. Louis adds to growing evidence that helping brain cells ...
Morning Overview on MSN

New compound clears toxic tau in lab model of frontotemporal dementia

Researchers at Washington University School of Medicine in St. Louis have shown that a small chemical compound can restore ...
EurekAlert!

The induction of autophagy-related genes in astrocytes proves to be a critical mechanism in effectively eliminating Aβ in the brains of AD patients (IMAGE)

The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and SQSTM1) in astrocytes are activated, Aβ is efficiently removed, which is ...
EurekAlert!

Increased expression of astrocyte-specific autophagy genes was observed in the brain tissues of AD patients (IMAGE)

(A) Increased expression of autophagy factors (LC3B, observed as blue dots) in astrocytes (GFAP) in the brain tissues of AD patients. (B) Increases in reactive astrocytes and autophagy gene expression ...
New Atlas

Cold plunges kick off cellular clean-up, could treat aging & disease

Enduring a week’s worth of cold water plunges can jolt the body’s cells into starting the process of autophagy to clean up and recycle old, worn-out, and broken parts, according to a new study. It ...
The Scientist

Understanding the Role of Autophagy in Infectious Disease

Josephine Thinwa shares her journey to becoming a physician scientist and how this led her to investigate the role of a neurologically important kinase in virus-induced autophagy. Just like people ...