An elusive step in the process of human DNA replication has been observed for the first time, report scientists at Penn State University. The scientists say they’ve discovered how a key step in human ...

Sliding clamps are ring-shaped proteins that encircle DNA and confer high processivity on DNA polymerases. Here we report the crystal structure of the five-protein clamp loader complex (replication ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 15 (Jul. 17, 2001), pp. 8376-8380 (5 pages) The β and proliferating cell nuclear antigen (PCNA) sliding ...

Crystal structures of the Escherichia coli DNA replication γ clamp loading complex and of a subunit of the clamp loader bound to a β clamp monomer provide a physical framework in which to view ...

According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human ...

An elusive step in the process of human DNA replication has been observed, for the first time, by scientists. The step, which is crucial for DNA replication in humans and other forms of life, had ...

Cells accumulate glutamate and related molecules under stress, and so formation of high-order protein assemblies under these conditions has important biological implications. Specifically, this would ...

Roemheld has introduced a range of compact, hydraulic sliding clamps designed for clamping in tight spaces on systems, press beds and rams. The new compact version provides the same clamping force as ...

The clamps can be installed on artisanal seam sheet roofs or industrial system seam sheet roofs made of coated steel, aluminum and other materials. Austrian mounting system provider Aerocompact has ...

CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) has announced an award of $1.06 million to the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) to develop ...