Top1 releases torsional stress during DNA replication and transcription in actively proliferating cells 1. Owing to the high proliferative rate of cancer cells, Top1 inhibitors have long been ...
The FDA has granted fast track designation to JSKN003, a biparatopic HER2-targeting antibody-drug conjugate (ADC), for the ...
The COVID-19 pandemic has now entered its eighth month, but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to spread in many parts of the world. Researchers are still ...
Immunome, Inc. (Nasdaq: IMNM), a biotechnology company focused on developing first-in-class and best-in-class targeted cancer ...
Randomized trial of vinorelbine compared with fluorouracil plus leucovorin in patients with stage IV non-small-cell lung cancer. Refractoriness to etoposide was defined as lack of response to ...
A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...
To initiate class switch recombination (CSR) activation-induced cytidine deaminase (AID) induces staggered nick cleavage in the S region, which lies 5' to each Ig constant region gene and is rich in ...
This is a preview. Log in through your library . Abstract Topoisomerases type I and type II are enzymes that unwind and wind DNA, in order to control the synthesis of proteins. Therefore, targeting ...
Alphamab Oncology (stock code: 9966.HK) announced that the first patient has been successfully dosed at Sun Yat-sen University Cancer Center in the phase I clinical study (Study ID: JSKN022-101) of ...
Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified ...
Women can be identified as being at increased risk for recurrence after primary surgery for breast cancer by a variety of pathologic factors including number of axillary lymph nodes involved with ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback