A case–control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, ...

Nortriptyline and other TCAs can help prevent migraine by increasing serotonin levels in the brain, which typically drop during a migraine episode. While nortriptyline can reduce migraine frequency, ...

Research that followed nearly 15,000 people in Scotland has shown that a class of older generation anti-depressant is linked to an increased risk of cardiovascular disease (CVD). The study showed that ...

Researchers have developed a highly efficient way to produce chiral multi-centered fused tricyclic compounds of which core structure is often found in bioactive compounds including medicines. Osaka ...

Many adults with diabetes and the associated complication of peripheral neuropathy, which can be painful as well as harmful, are often prescribed drugs at doses and for durations that could impose an ...

Use of tricyclic antidepressants (TCAs) is associated with decreased liver fibrosis progression and delayed time to cirrhosis development, according to a large cohort of veterans with hepatitis C ...

November 30, 2010 — Findings from a prospective cohort study released today suggest tricyclic antidepressants (TCAs) are associated with a 35% increased risk for cardiovascular disease (CVD), which is ...

Medications for diverticulitis include antibiotics, acetaminophen, antispasmodics, and tricyclic antidepressants. Some over-the-counter medications may worsen the condition, so it is important to ...

The novel tricyclic compounds based on a quinazoline scaffold of this study were tested by us, for example, to attenuate glutamate-induced cell death of the human glioblastoma cell line U118MG and to ...