This has turned into a three part look at GLP-1s. While writing my thoughts on GLP-1s, I thought that Dr Robert Cywes would be an excellent podcast guest on the topics of carb addiction, obesity and ...

This is the second of a two-part note, which covers: * What are GLP-1 receptor agonists? * Which were the first GLP-1s approved for type 2 diabetes (T2D)? When were they approved? Who makes them? Are ...

This is the first of a two-part note, which covers: * What are GLP-1 receptor agonists? * Which were the first GLP-1s approved for type 2 diabetes (T2D)? When were they approved? Who makes them? Are ...

* Last week's note reviewed a Korean population study, which led to headlines such as " Taking statins could slash dementia risk." The claims were not robust. * This week's note reports findings from ...

This week’s note features a podcast with Professor Norman Fenton. Norman is Professor Emeritus of Risk at Queen Mary University of London (retired as Full Professor December 2022) and a Director of ...

* This week's paper used a technique that is generally considered to be the highest level of evidence (systematic review and meta-analysis). It turned out to be a good example of the technique only ...

* This is the second of a two part note looking at metabolism. * Benedict is credited as the first person to study the impact of a calorie deficit in human beings (1917). * Benedict’s research took ...

* This week’s note contains a podcast with Hannah Sutter and research about ketogenic diets for epilepsy. Hannah is particularly interested in (and provides food for) the ketogenic diet for epilepsy – ...

This is the 700th Monday note. In this landmark post, I share the key things that I have learned over the past 14 years ...

* I read a book called “Burn: The misunderstood science of metabolism” by Dr Herman Pontzer. Pontzer had lived with and studied the Hadza – a modern hunter-gatherer people living in northern Tanzania.

* A recent obesity Congress generated headlines about the 'weight loss jab' cutting heart disease. Two papers were referenced in a press release from the Congress – one has been published. * The ...

Executive summary * The National Institute for Clinical Excellence (NICE) is the organisation in the UK that sets medical guidelines for every drug, every intervention, and every procedure. * NICE ...