The EMBO Journal

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Sphingosine and constrained analogs like ...
The New England Journal of Medicine

Identification of Hepatic-like EPO as a Cause of Polycythemia

Shown are the genetic variants identified in EPO, the gene encoding erythropoietin (EPO), in patients with erythrocytosis. The term cDNA denotes complementary DNA, F female, M male, and NA not ...
ahajournals.org

Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

We leveraged transcriptomic profiling and deep phenotyping of the largest multicenter PAH lung biobank to date (96 disease and 52 control) by integration with clinicopathologic data, genome-wide ...
ahajournals.org

Endothelial Serotonin Receptor 1B Acts as a Mechanosensor to Drive Atherosclerosis

Atherosclerosis is characterized by the accumulation of fatty and fibrotic plaques, which preferentially develop at curvatures and branches along the arterial trees that are exposed to disturbed flow.
The EMBO Journal

FNDC1 is a myokine that promotes myogenesis and muscle regeneration

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Muscle injury induces expression of myokines ...
C&EN

Small-Angle X-ray Scattering (SAXS) Combined with SAXS-Driven Molecular Dynamics for Structural Analysis of Multistranded RNA Assemblies

Nucleic acids (RNA and DNA) play crucial roles in all living organisms and find wide utility in clinical settings. The convergence of rationally designed nucleic acid multistranded assemblies with ...
C&EN

Retraction of “Supramolecular Nanotubes Functioning as Morphology Regulators for Fluid-State Molecular Assemblies”

The authors retract the published paper “Chem. Mater. 2022, 34, 9425–9436. DOI: 10.1021/acs.chemmater.2c01722” because, upon investigation by the National Institute of Advanced Industrial Science and ...
ascopubs.org

Impact of Postoperative Radiotherapy on the Prognosis of Early-Stage (pT1-2N0M0) Oral Tongue Squamous Cell Carcinoma

This retrospective cohort study included 528 patients diagnosed between October 2009 and December 2021. Clinicopathological characteristics and treatments with or without PORT were analyzed for their ...
ascopubs.org

Genomic Classification and Individualized Prognosis in Multiple Myeloma

Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study Outcomes for patients ...
bleedingcool

Spartan Army Commander Figure Debut from Sideshow and TBLeague

"Sideshow and TBLeague are proud to present the iconic Spartan Army Commander (Gold) Sixth Scale Figure! The Spartan Army Commander (Gold) comes equipped with a stunning set of golden armor along with ...
bleedingcool

Muhammed Ali Stings Like a Bee with IconiQ Studios New 1/6 Figure

Muhammed Ali is back and ready to get a couple of knockouts in your collection as IconciQ Studios reveals their newest collectible. The 1/6 Scale Figure stands 12" tall and will feature a fully ...