After Demi Moore lost the best actress Oscar to a younger star, Mikey Madison, fans of "The Substance" couldn't help but point out the irony.

Going into the 2025 Academy Awards, Demi Moore had become a favorite for the Best Actress category. The 62-year-old’s portrayal of an aging, insecure actress deemed past her prime who took a black-market drug to try to become a “younger,

"The Substance" actress also told Madison she "can’t wait to see what you do next."Demi Moore is taking a (very classy) moment to reflect on the monumental awards season she just had.Thanks to key precursor wins at the Golden Globes and SAG Awards — and endlessly charming and passionate speeches at said ceremonies — many awards prognosticators penciled in Moore to win the Oscar for Best Actress for her role in The Substance at Sunday night's Academy Awards.