The total driving distance from Louisville, KY to Greenville, SC is 411 miles or 661 kilometers. Your trip begins in Louisville, Kentucky. It ends in Greenville, South Carolina.

The cheapest way to get from Louisville to Greenville costs only $92, and the quickest way takes just 5 hours. Find the travel option that best suits you. Rome2Rio

The total driving distance from Louisville, KY to Greenville, SC is 411 miles or 661 kilometers. The total straight line flight distance from Louisville, KY to Greenville, SC is 300 miles . This is equivalent to 483 kilometers or 261 nautical miles .

How far is Greenville, South Carolina from Louisville, Kentucky? The driving distance is 411 miles.

Get a quick answer: It's 411 miles or 661 km from Louisville to Greenville (South Carolina), which takes about 6 hours, 23 minutes to drive.

This is the distance between Greenville (South Carolina) and Louisville (Kentucky) calculated in kilometers, miles and nautical miles. On the map you can see the driving itinerary, fuel consumption and estimated driving time from Greenville to Louisville.

How far is Louisville, Kentucky from Greenville, South Carolina? The driving distance is 411 miles.

Find out how many hours from Louisville to Greenville, SC by car if you're planning a road trip. If you want to explore small towns along the way, get a list of cities between Louisville, KY and Greenville, SC .

Get a quick answer: It's 411 miles or 661 km from Greenville (South Carolina) to Louisville, which takes about 6 hours, 23 minutes to drive.

Fly one-way from Louisville to Greenville-Spartanburg starting at $124. Bundle your Southwest Airlines® flight with a hotel or rental car booking and find even more savings.