Signal-regulatory protein alpha - Wikipedia
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells [citation needed] or neurons. SIRPα …
SIRPA Gene - GeneCards | SHPS1 Protein | SHPS1 Antibody
Nov 14, 2025 · Complete information for SIRPA gene (Protein Coding), Signal Regulatory Protein Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. …
SIRPA signal regulatory protein alpha [ (human)]
Feb 8, 2025 · Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity. SIRPalpha might play an important role in the progression of oral …
Sirpα on tumor-associated myeloid cells restrains antitumor
Jan 10, 2024 · Jin and colleagues show that myeloid cells in patients with colorectal cancer exhibit increased expression of SIRPA and that Sirpa deficiency on macrophages reprograms the …
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint …
Nov 3, 2022 · Zhou et al. reveal that tumor-intrinsic SIRPA can enhance the sensitivity to anti-PD-1 treatment in melanoma patients, whereas macrophage SIRPA has a well-established role as …
SIRPA Gene: Function, Research, and Clinical Applications
Learn about the SIRPA gene, its role in immunity, disease, and potential therapeutic applications. Explore research on SIRPA, its interactions with CD47, and its implications for cancer …
SIRPα: A key player in innate immunity - Wiley Online Library
Sep 6, 2023 · Additionally, Sirpa has been identified as a T1D risk gene in the nonobese diabetic mice model [58], and it has been proposed that SIRPα controls insulin secretion and …
SIRPA - signal regulatory protein alpha Gene | MedChemExpress
Summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are …
Sirpa MGI Mouse Gene Detail - MGI:108563 - signal-regulatory …
View mouse Sirpa Chr2:129434755-129474148 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Signal-Regulatory Protein Alpha - an overview - ScienceDirect
Signal regulatory protein (SIRP)α, also known as SHPS-1 or SIRPA, is a transmembrane protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic …