Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to …

Jun 6, 2025 · In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic. In October 2023, the first volunteer was treated in a Phase 1, …

Apr 17, 2025 · TREM2 created quite the buzz at this year’s AD/PD meeting, held April 1-5 in Vienna. In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings …

TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease …

Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease. …

R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. Several murine Trem2 R47H knock-in lines have been created using CRISPR/Cas9 …

Apr 17, 2025 · Ever since the discovery of AD risk-stoking variants of TREM2, the microglial receptor has given scientists seeking to nail down its function a run for their money. It binds …

Feb 7, 2018 · The H157Y mutation reduced activation in response to phospholipid ligands in 2B4 T cells engineered to turn on GFP expression when TREM2 was engaged (Song et al., 2017) …

Sep 12, 2022 · Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in …

Nov 3, 2023 · Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating …