Video: La vía apoptótica intrínseca

Draw the following apoptotic pathway, which operates in human immune cells. A death signal is received when a molecule called Fas binds its cell-surface receptor. The binding of many Fas molecules to receptors causes receptor clustering. The intracellular regions of the receptors, when together, bind proteins called adaptor proteins. These in turn bind to inactive molecules of caspase- 8, which become activated and then activate caspase-3. Once activated, caspase-3 initiates apoptosis. | Numerad

Natural Killer cell kills the cancer cell in two simple ways: 1. “Death signal” way (extrinsic apoptosis) NK cell shows a special key (FasL or TRAIL). The cancer cell has a lock (death receptor). Key fits lock → instant message inside: “self-destruct now.” The cancer cell calmly chops itself into small, tidy pieces and dies without making a mess. 2. “Bullet poison” way (granule pathway) NK cell shoots tiny holes with perforin. Poison enzymes (granzymes) slip through the holes. Poison turns on th

"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade